PhD student
Haiyu Wang
Research
Autoantibodies are present in many autoimmune diseases such as Rheumatoid Arthritis. Several of these autoantibodies activate the complement system, leading to tissue damage. My research focuses on developing new treatment strategies by inhibiting complement activity only locally. One approach is to use bi-specific antibodies, of which one arm binds to a local antigen, and the other arm binds to an endogenous complement inhibitor. By exploring different parental antibodies and different formats of antibodies, I aim to develop a new strategy for treating autoimmune diseases.
Curriculum vitae
I obtained my bachelor degree of Veterinary Medicine in Ji Lin university (Chang Chun, China). After graduation in 2017, I moved to Peking Union Medical College (Tsinghua university) to do my master. My research was focused on cell fate decision in early embryo development, where I obtained experience and expertise both on lab work and animal experimentation. After obtaining my master’s degree in 2021, I came to the Netherlands and joined Prof. Trouw’s group, to start my PhD work on targeted, local inhibition of the complement system.
Publications
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Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators
Haiyu Wang; Fleur S. van de Bovenkamp; Douwe J. Dijkstra; Leoni Abendstein; Nicole V. Borggreven; Jos Pool; Rob Zuijderduijn; Christoph Gstöttner; Kyra A. Gelderman; Timon Damelang et al
10.3389/fimmu.2024.1288597
Groups:
Complement and antibodies