Starting at 2018 up until today, I’m assigned in combined roles to perform research activities in the Complement & Antibodies group of Dr. Leendert Trouw, and serving as managerial assistant for the Transplantation Immunology and HLA diagnostics groups.
Additionally, I am supporting our department in coordinating and performing operational tasks together with the laboratory council, in order to facilitate the on-going research and diagnostic activities of the different research groups and the HLA-laboratory.
This includes initiating solutions based upon the principles of the LEAN-philosophy with regard to our incoming supplies, the management of laboratory rooms and equipment, and to practically prepare and anticipate on necessary changes the department may face in the future.
It’s my personal mission to make sure everyone in our department is able to perform his or her work in a safe, efficient and practical manner, since only together we can make a difference.
After obtaining my Bachelor degree of Applied Science at the Hogeschool Leiden in 2012, I started my career at Janssen Pharmaceuticals as a junior technician within the QC-department of Microbiology. With the experience of GMP and quality control, I joined the LUMC in 2013, to continue as a research technician in the group of Prof. Dr. Wim Fibbe.
During the years 2013 – 2017, I was responsible for the ex-vivo expansion of Mesenchymal Stromal Cells (MSC’s) in a cleanroom environment for their use in clinical trials such as the kidney-based Triton and Neptune studies, as well as the Hovon113-study for the treatment of severe steroid-refractory acute Graft-versus-Host-Disease (GvHD). Additionally, I was involved in the scope of the TAS A+B study to investigate the possibility of acquiring functional MSC’s out of adipose tissue.
Both projects were under supervision of Dr. Helene Roelofs & Prof. Dr. Jaap-Jan Zwaginga.
Lastly, I’ve performed research in the stem-cell niche field led by Dr. Melissa van Pel to gain insight in the process of hematopoietic stem-cell mobilization under the effects of administration of MSC’s and G-CSF.
Mesenchymal stromal cells induce a permissive state in the bone marrow that enhances G-CSF-induced hematopoietic stem cell mobilization in mice
de Kruijf EFM, Zuijderduijn R, Stip MC, Fibbe WE, van Pel M.
Exp Hematol. 2018 Aug;64:59-70.