As a senior research technician and lab manager in the Arens group I’m involved in several different immunology projects. These projects include a) investigating the effect of chemotherapeutics on the immune system, b) developing vaccines that elicit T cells and antibodies against cytomegalovirus (CMV) and SARS-CoV-2, and c) understanding the cellular and molecular mechanisms of cancer immunotherapy.
In 2001 I finished my laboratory college education in Rotterdam. After an internship at the Erasmus Medical Center Rotterdam at the department of Surgery, I started working in the Tumor Immunology group of the department of Immunohematology and Blood Transfusion at the LUMC. Since 2011 I’m working as a senior research technician / lab manager in the group of Ramon Arens.
Interleukin-6-mediated resistance to immunotherapy is linked to impaired myeloid cell function.
Beyranvand Nejad E, Labrie C, van der Sluis TC, van Duikeren S, Franken KLMC, Roosenhoff R, Arens R, van Hall T, van der Burg SH.
Int J Cancer. 2021;148(1):211-225.
PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors.
Beyrend G, van der Gracht E, Yilmaz A, van Duikeren S, Camps M, Höllt T, Vilanova A, van Unen V, Koning F, de Miranda NFCC, Arens R, Ossendorp F.
J Immunother Cancer. 2019; 7(1):217.
Vaccine-induced effector-memory CD8+ T cell responses predict therapeutic efficacy against tumors
van Duikeren S, Fransen MF, Redeker A, Wieles B, Platenburg G, Krebber WJ, Ossendorp F, Melief CJ, Arens R.
J Immunol. 2012;189(7):3397-403.