Nannan Guo

Research

In recent years, the development of a variety of single-cell technologies increased recognition of cellular heterogeneity both in physiological and pathological contexts. Single-cell technologies based on RNA sequencing and mass cytometry (CyTOF) have been utilized to investigate cellular heterogeneity and identify novel cellular subsets, and to discover biomarkers with clinical value. So we focus on identify the phenotype of skin disease-associated immune subsets by the determination of the composition and polarization of the adaptive and innate immune system in skin and blood by CyTOF.

Imaging mass cytometry (IMC) is an extension of mass cytometry, which couples a laser ablation system with a mass cytometer and therefore has the ability to analyze up to 40 markers in a single tissue section. Here the simultaneous analysis of the  adaptive and innate immune system reveals potential cross-talk between skin disease-associated response in these immune compartments in situ.

Curriculum Vitae

For my masters I studied Biochemistry and Molecular Biology in Jilin University in Changchun, China. After I finished my masters I started my PhD in the group of Frits Koning since 2018