Microbiota-specific CD4+ T cells are believed to be major drivers of inflammation in Inflammatory Bowel Disease (IBD). We and others have identified different subsets of CD4+ T cells that are enriched in inflamed mucosa from IBD patients, but the functional properties and interactions between these subsets and other cellular players and bacterial species in the lamina propria remains to be elucidated. I joined Frits Koning’s group in 2020 as a PhD student and my work will focus on understanding the functional role of different CD4+ T cell subsets in driving pathology in IBD, especially by using spectral cytometry and imaging technologies. We hope to provide some ideas for a better management of chronic inflammation and development of more effective therapies in IBD.
I studied for my bachelor’s degree in Clinical Medicine at Chongqing Medical University in China. After graduation in 2017, I moved on to my master’s studies in Tongji Medical College, Huazhong University of Science and Technology. During this period I joined Yu Hu’s group in the Institute of Hematology, focusing on the research about the bone marrow microenvironment in multiple myeloma. I also performed clinical practice at the Department of Hematology in Wuhan Union Hospital. In December 2020, I started my PhD program in the Immunology department of LUMC under the supervision of Frits Koning and Fernanda Pascutti.