Prof. Dr. Jannie Borst
Jannie Borst obtained a Master degree in Biology with Chemistry at Leiden University in 1980. She did the major part of her PhD work at the Dana Farber Cancer Institute, Harvard Medical School in Boston, under supervision of biochemist prof. Cox P. Terhorst. She obtained her PhD degree from Leiden University in 1985, with prof. Jon J. van Rood as promotor. In 1987, she started her independent career as research group leader at the Netherlands Cancer Institute, with the aid of a 5-year personal Huygens fellowship from The Netherlands Organization for Scientific Research. In 1992, she obtained a staff scientist position at the NKI-AVL and from 2002 to 2019, she has also been the head of the Division of Immunology at that institute. From 1999 to 2019, she was in addition professor in Experimental Oncology at the University of Amsterdam and coordinator of the Biomedical Master track Oncology. In January 2019, she has become the head of the Department of Immunohematology and Blood Transfusion at Leiden University Medical School and she will continue her research line in this position.
CD4+ helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment.
Lei X, Khatri I, de Wit T, de Rink I, Nieuwland M, Kerkhoven R, van Eenennaam H, Sun C, Garg AD, Borst J & Xiao Y
Nat Commun. 14:217, 2023
Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy
Guelen, L., Fischmann, T.O., Wong, J., Mauze, S., Guadagnoli, M., Bąbała, N., .... Borst J, Beebe AM & Van Eenennaam H.
J. Immunother. Cancer. 10:e005049, 2022
Stable human regulatory T cells switch to glycolysis upon TNF receptor 2 costimulation
de Kivit, S., Mensink, M #, Hoekstra, A.T., Berlin, I., Derks, R.J.E., Both, D., Aslam, M.A., Amsen, D., Berkers, C.R. & Borst, J.
Nat. Metabol. 2: 1046-1061, 2020