T cells play a central role in cancer immunity. The spatio-temporal availability of co-stimulatory and co-inhibitory molecules contributes to the differential programming of T cells resulting in expansion and differentiation into various subsets. At present it is not known which and when costimulatory signals control the recruitment of CD4 and CD8 T cells in human lymph nodes and how these signals impact T cell (dys)function. During my PhD, I aim to dissect at a molecular and cellular level how collective co-signals are integrated to instruct the fitness of lymph node T cells. These objectives will be probed and aided by using high-dimensional cytometry and CRISPR-Cas technology. The ultimate aim is to use this knowledge to rationally improve immunotherapy of cancer.
I studied Internal Medicine at the Southern Medical University in China. During my Master studies, I main researched the Hematology diseases and I also performed internships at the Nanfang hospital, Guangzhou of China. After obtaining my Master’s degree, currently I am a PhD student in the group of Ramon Arens in November 2022.
Human Amniotic Mesenchymal Stem Cells Inhibit aGVHD by Regulating Balance of Treg and T Effector Cells.
Gao Y, Li W, Bu X, Xu Y, Cai S, Zhong J, Du M, Sun H, Huang L, He Y, Hu X, Liu Q, Jin H, Wang Q, Ping B.
J Inflamm Res. 2021; 14:3985-3999