The hematopoiesis is a mechanism during which self-renewing hematopoietic stem cells are able to differentiate into the more developmentally restricted cells of the myeloid, lymphoid and erythroid lineages. The self-renewal program and hierarchical pattern of the differentiation are highly controlled by signalling pathways and molecular mechanisms. Moreover, this developmental cascade is influenced by changes in the chromatin landscape and transcription factor network. However, many of the epigenetic factors involved in these processes remain unknown. Flowcytometry, epigenomics and in vivo studies will help us to dissect the functions of key epigenetics regulators during the immune cell development and to better understand the crucial transcriptional and epigenetic programs of the cell fate decisions in mammals.
I got my Bachelor Degree in Biotechnology at the University of Urbino (Italy) and my Master Degree in Medical Biotechnologies at the University of Siena (Italy). After my studies, I joined the group of Prof. Reuven Agami (Netherlands Cancer Institute, Amsterdam) for a research internship. In June 2018 I started my PhD at the Leiden University Medical Centre in the group of Dr. Lucia Daxinger (Human Genetics department) in collaboration with the group of Prof. Frank Staal (Immunology Department).