Aline Zbinden
RESEARCH
My research interest lies in the captivating field of thymus biology, as it is the site where T cells develop, playing a critical role in T-cell diversity and the establishment of self-tolerance. Understanding the complex biology of the thymus not only provides insights into fundamental aspects of immunology but also holds promising implications for clinical applications. Currently, our focus is on deriving thymic epithelial cells from induced pluripotent stem cells (iPSCs) for autologous transplantation in athymic patients.
CURRICULUM VITAE
I hold a master degree in Life Sciences and Technology at EPFL (Switzerland). I moved to Berkeley (USA) to complete my master project on the multivalency of bFGF (Material Science, Healy Lab). Then, I pursed a PhD in biology at the University of Tübingen in Germany, where my focus was on the development of advanced in vitro models for the diabetes research field (Faculty of Medicine, Schenke-Layland Lab). In 2021, I was awarded a Postdoc Mobility grant from the Swiss National Foundation (SNF) to join the laboratory of Prof. Staal.
Publications
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Stem Cell-Based Disease Models for Inborn Errors of Immunity
Zbinden A., Canté-Barrett K., Pike-Overzet K. & Staal F.J.T.
Cells, 2022; 11(1), 108. https://doi.org/10.3390/cells11010108
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Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration
Zbinden A.#, Layland S.L.#, Urbanczyk M., Carvajal D.A., Marzi J., Zauner M., Hammerschmidt ..., Seifert M. and Schenke-Layland K.
Advanced Science, 2020; https://doi.org/10.1002/advs.202002500
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Collagen and endothelial cell co-culture improves β-cell functionality and rescues pancreatic ECM
Zbinden A.#, Urbanczyk M.#, Layland S.L., Becker L., Marzi J., Bosch M., Loskill P., Duffy G.P. & Schenke-Layland K.
Tissue Engineering Part A, 2020;. https://doi.org/10.1089/ten.tea.2020.0250
