PhD student
Liseanne van t Hof
Research
From 2013 onwards, I have been studying at the LUMC as a bachelor student in Biomedical Sciences and later as a master student in both Medicine and Biomedical Sciences. After obtaining both degrees, I received the MD-PhD grant to continue as a PhD candidate in the field of Reproductive Immunology. The unique maternal-fetal immune interactions during pregnancy are intriguing and I am passionate to contribute to this field by performing translational research.
During my first master’s internship, we investigated the relationship between expression of immune checkpoint inhibitory ligands and the complication of preeclampsia in term placenta of oocyte donation pregnancies. I continued with a second project on maternal-fetal HLA compatibility in uncomplicated and preeclamptic naturally conceived pregnancies. Together with my colleagues, I will proceed with both subjects during my current PhD training, to further explore the impact of changes in immune checkpoint inhibition and maternal-fetal HLA compatibility on pregnancy outcome. I hope to contribute to elucidating to what extent these immunological mechanisms are essential for a healthy human pregnancy and thus, how we can help to prevent and treat pregnancy complications.
Curriculum vitae
After obtaining my bachelor degree in Biomedical Sciences at Leiden University and Leiden University Medical Center, I was admitted to the pre-masterprogram Medicine. Thereafter, I combined the master programs of Biomedical Sciences and Medicine and graduated from both in 2022. In May 2022, I started my PhD training at the department of Immunology and the department of Gynaecology and Obstetrics at the Leiden University Medical Center under the guidance of prof. dr. J.G. Borst, dr. M. Eikmans and dr. M.L.P. van der Hoorn.
Publications
-
Maternal-Foetal HLA-DQB1 Incompatibility Is Associated With Pregnancy-Induced Hypertensive Disorders In a Genetically Isolated Population
van 't Hof LJ, van der Hoorn MP, Migdis S, Haasnoot GW, Peereboom ETM, Spierings E, van der Linden PJE, Anholts JDH, de Vreede H (...) Lashley LEELO
HLA 2025 August 22
-
Cervical EVT isolation for non-invasive fetal HLA typing in early pregnancy is limited by purity and maternal cell contamination; a methodological comparison
van 't Hof LJ, Kapsenberg JM, Drabbels JJM, van der Meeren LE, Roelen DL, Eikmans M, van der Hoorn MP.
Front Immunol 2025 May 9
-
Maternal-Fetal HLA Compatibility in Uncomplicated and Preeclamptic Naturally Conceived Pregnancies
van 't Hof LJ, Schotvanger N, Haasnoot GW, van der Keur C, Roelen DL, Lashley LEELO, Claas FHJ, Eikmans M, van der Hoorn MP.
Front Immunol 12:673131, 2021.
-
An Unusual Presentation of Pyelonephritis: Is It COVID-19 Related?
van ‘t Hof LJ, Pellikaan L, Soonawala D, Roshani H.
SN Compr. Clin. Med. 2021. https://doi.org/10.1007/s42399-021-00909-0
-
Decreased expression of ligands of placental immune checkpoint inhibitors in uncomplicated and preeclamptic oocyte donation pregnancies
van 't Hof LJ, Dijkstra KL, van der Keur C, Eikmans M, Baelde HJ, Bos M, van der Hoorn MLP
J Reprod Immunol. 2020 Sep 3;142:103194. doi: 10.1016/j.jri.2020.103194
