Professor - Group leader
Prof. dr. Ramon Arens
Academic career
Ramon Arens studied Medical Biology at the University of Amsterdam and carried out his PhD research at Sanquin and Amsterdam University Medical Center in the laboratory of Prof. Dr. René van Lier. After obtaining his PhD in 2003, he performed postdoctoral research in the group of Prof. Dr. Ton Schumacher at the Immunology Division of the Netherlands Cancer Institute till 2006, which was followed by a position as a research scientist at the La Jolla Institute of Allergy and Immunology (USA). In 2010 he became Assistant Professor in the Immunohematology department at the LUMC, and in 2017 Associate Professor. He became full professor within the Immunology department (LUMC) in 2024. He is also appointed as Honorary investigator at the University of Oxford.
Publications
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Inhibiting the NADase CD38 improves cytomegalovirus-specific CD8+ T cell functionality and metabolism
Mülling N, Behr FM, Heieis GA, Boss K, van Duikeren S, van Haften FJ, Pardieck IN, van der Gracht ET, Vleeshouwers W, van der Sluis TC, de Graaf JF, Veerkamp DM, Franken KL, Lei X, van de Sand L, van der Burg SH, Welters MJ, Heidt S, .... Arens R.
J Clin Invest 2024;134(17):e179561. doi: 10.1172/JCI179561.
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OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum
van der Sluis TC, Beyrend G, van der Gracht ET, Abdelaal T, Jochems SP, Belderbos RA, Wesselink TH, van Duikeren S, Haften FJ, Redeker A, Beyranvand Nejad E, Camps M, Franken KL, .... Ossendorp F, Arens R.
Cell Rep Med. 2023; 100939. doi: 10.1016/j.xcrm.2023.100939
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Delayed vaccine-induced CD8+ T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication
van der Sluis TC, van Haften FJ, van Duikeren S, Pardieck IN, de Graaf JF, Vleeshouwers W, van der Maaden K, Melief CJM, van der Burg SH, Arens R.
J Immunother Cancer. 2023; 11(11):e007158. doi: 10.1136/jitc-2023-007158.
Groups:
Tutors | T cell regulation
