Dr. Anouk von Borstel
Curriculum vitae
In 2019, I obtained my PhD at the University Medical Center Groningen and the University of Groningen, where my research focused on B cells in autoimmunity. Following my PhD, I spent six years as a postdoctoral researcher at Monash University in Melbourne. During the first five years, I investigated gamma delta T cell biology, primarily in the context of infectious disease. Subsequently, I conducted 1.5 years of postdoctoral research on allergen-specific B cells and their role in allergen immunotherapy in allergic patients.
Throughout this period, I supervised three PhD students, managed a small research team, and published several scientific articles. I was also a member of various scientific committees and acted as a reviewer for multiple scientific journals. During my scientific career, I have gained extensive experience in flow cytometry, in particular the phenotypic and functional characterization of immune cell subsets.
In 2024, I started my current position as a medical immunologist in training (laboratory specialist medical immunology). I am employed at the HLA laboratory of Leiden University Medical Center, with my training taking place across several departments within the LUMC, as well as at Erasmus Medical Center and Reinier Haga Hospital in Delft. During this three-year training programme, I will focus on transplantation, immunodeficiencies, and hematological malignancies.
Publications
-
Expansion of phenotypically modified type 2 memory B cells after allergen immunotherapy
Anouk von Borstel, Simone Reinwald, Pei M Aui, Craig I McKenzie, Nirupama Varese, P Mark Hogarth, Mark Hew, Robyn E O'Hehir, Menno C van Zelm
Allergy 80(3): 867 (2024)
-
Cytomegalovirus drives Vdelta1+ gamma delta T cell expansion and clonality in common variable immunodeficiency
Samantha Chan, Benjamin Morgan, Michelle K Yong, Mai Margetts, Anthony J Farchione, Erin C Lucas, Jack Godsell, Nhi Ai Giang, Charlotte A Slade, Anouk von Borstel, Vanessa L Bryant, Lauren J Howson
Nature Communications 15(1): 4286 (2024)
-
Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive gamma delta T cell repertoire
Anouk von Borstel, Priyanka Chevour, Daniel Arsovski, Jelte MM Krol, Lauren J Howson, Andrea A Berry, Cheryl L Day, Paul Ogongo, Joel D Ernst, Effie YH Nomicos, Justin A Boddey, Edward M Giles, Jamie Rossjohn, (...) Peter D Crompton, Martin S Davey
Science Translational Medicine 13(622): eabe7430 (2021)
-
Transcriptional profiling of human Vdelta1 T cells reveals a pathogen-driven adaptive differentiation program
Jack L McMurray, Anouk von Borstel, Taher E Taher, Eleni Syrimi, Graham S Taylor, Maria Sharif, Jamie Rossjohn, Ester BM Remmerswaal, Frederike J Bemelman, Felipe A Vieira Braga, Xi Chen, (...) Martin S Davey, Carrie R Willcox, Benjamin E Willcox
Cell Reports 39(8) (2022)
-
Recognition of the antigen-presenting molecule MR1 by a Vdelta3+ gamma delta T cell receptor
Michael T. Rice, Anouk von Borstel, Priyanka Chevour, Wael Awad, Lauren J. Howson, Dene R. Littler, Nicholas A. Gherardin, Jérôme Le Nours, Edward M. Giles, Richard Berry, Dale I. Godfrey, Martin S. Davey, Jamie Rossjohn, Benjamin S. Gully
PNAS 118(49): e2110288118 (2021)
Groups:
HLA diagnostics laboratory
